Botox January 19, 2023 Botox® is made of purified proteins used safely and naturally to temporarily improve the look of moderate to severe wrinkles. Botox works by blocking nerve signals that direct facial muscles to contract during facial expressions. When muscles are prevented from contracting, the lines and folds in the skin’s surface are prevented from forming. Lines continue to improve for up to 30 days, and the results can last for up to 6 months.